Heide Brandhorst

• Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.

  Journal article

  Brandhorst D. et al, (2013), Apoptosis, 18, 681 - 688

• Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

  Journal article

  Brandhorst H. et al, (2013), Cell Transplant, 22, 1477 - 1483

• Oxygen-charged HTK-F6H8 emulsion reduces ischemia-reperfusion injury in kidneys from brain-dead pigs.

  Journal article

  Asif S. et al, (2012), J Surg Res, 178, 959 - 967

• Oxygen-charged HTK-F6H8 emulsion reduces ischemia-reperfusion injury in kidneys from brain-dead pigs

  Journal article

  Asif S. et al, (2012), Journal of Surgical Research, 178, 959 - 967

• Using HTK for prolonged pancreas preservation prior to human islet isolation.

  Journal article

  Caballero-Corbalán J. et al, (2012), J Surg Res, 175, 163 - 168

• Using HTK for prolonged pancreas preservation prior to human islet isolation

  Journal article

  Caballero-Corbalán J. et al, (2012), Journal of Surgical Research, 175, 163 - 168

• Chemical Oxygenation of Pancreatic Tissue Prior to Islet Isolation and Transplantation

  Chapter

  Brandhorst H. et al, (2012), ORGAN DONATION AND TRANSPLANTATION – PUBLIC POLICY AND CLINICAL PERSPECTIVES, 217 - 238

• Quantification of the islet product: presentation of a standardized current good manufacturing practices compliant system with minimal variability.

  Journal article

  Friberg AS. et al, (2011), Transplantation, 91, 677 - 683

• The effect of truncated collagenase class I isomers on human islet isolation outcome.

  Journal article

  Brandhorst H. et al, (2010), Transplantation, 90, 334 - 335

• Mammalian tissue-free liberase: a new GMP-graded enzyme blend for human islet isolation.

  Journal article

  Caballero-Corbalán J. et al, (2010), Transplantation, 90, 332 - 333

• Erratum: Vitacyte collagenase HA: A novel enzyme blend for efficient human islet isolation (Transplantation (2009) 88 (1400))

  Journal article

  Caballero-Corbalán J. et al, (2010), Transplantation, 89

• A new oxygen carrier for improved long-term storage of human pancreata before islet isolation.

  Journal article

  Brandhorst H. et al, (2010), Transplantation, 89, 155 - 160

• Large-scale comparison of Liberase HI and collagenase NB1 utilized for human islet isolation.

  Journal article

  Brandhorst H. et al, (2010), Cell Transplant, 19, 3 - 8

• Vitacyte collagenase HA: a novel enzyme blend for efficient human islet isolation.

  Journal article

  Caballero-Corbalán J. et al, (2009), Transplantation, 88, 1400 - 1402

• Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation.

  Journal article

  Brandhorst H. et al, (2009), Transpl Int, 22, 1017 - 1022

• Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.

  Journal article

  Lai Y. et al, (2009), Islets, 1, 19 - 25

• The importance of tryptic-like activity in purified enzyme blends for efficient islet isolation.

  Journal article

  Brandhorst H. et al, (2009), Transplantation, 87, 370 - 375

• Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.

  Journal article

  Iken M. et al, (2009), Cell Transplant, 18, 745 - 751

• Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation (Xenotransplantation 15, 225-234)

  Journal article

  Goto M. et al, (2008), Xenotransplantation, 15

• Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation.

  Journal article

  Goto M. et al, (2008), Xenotransplantation, 15, 225 - 234

• Degraded collagenase deteriorates islet viability.

  Journal article

  Brandhorst H. et al, (2008), Transplant Proc, 40, 370 - 371

• New class of oxygen carriers improves islet isolation from long-term stored rat pancreata.

  Journal article

  Brandhorst H. et al, (2008), Transplant Proc, 40, 393 - 394

• The ratio between collagenase class I and class II influences the efficient islet release from the rat pancreas.

  Journal article

  Brandhorst H. et al, (2008), Transplantation, 85, 456 - 461

• Human islet separation utilizing a closed automated purification system.

  Journal article

  Friberg AS. et al, (2008), Cell Transplant, 17, 1305 - 1313

• Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model.

  Journal article

  Eich T. et al, (2007), Transplantation, 84, 893 - 898

• Effect of pretransplant preconditioning by whole body hyperthermia on islet graft survival.

  Journal article

  Brandhorst H. et al, (2007), Cell Transplant, 16, 707 - 715

• Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.

  Journal article

  Brandhorst D. et al, (2006), Xenotransplantation, 13, 465 - 470

• Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.

  Journal article

  Linn T. et al, (2006), Clin Exp Immunol, 144, 179 - 187

• Induction and amelioration of environmental stress in isolated islets until transplantation

  Journal article

  Brandhorst D. et al, (2006), Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 6, 206 - 218

• Oxygen and pancreas preservation.

  Journal article

  Mirbolooki M. and Lakey JR., (2006), Transplantation, 81

• Porcine islet graft function is affected by pretreatment with a caspase-3 inhibitor.

  Journal article

  Brandhorst D. et al, (2006), Cell Transplant, 15, 311 - 317

• Adjustment of the ratio between collagenase class II and I improves islet isolation outcome.

  Journal article

  Brandhorst D. et al, (2005), Transplant Proc, 37, 3450 - 3451

• Effect of stable glutamine compounds on porcine islet culture.

  Journal article

  Brandhorst H. et al, (2005), Transplant Proc, 37, 3519 - 3520

• Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets.

  Journal article

  Lai Y. et al, (2005), Transplantation, 79, 1530 - 1536

• Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.

  Journal article

  Brandhorst D. et al, (2005), Transplantation, 79, 433 - 437

• Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.

  Journal article

  Brandhorst D. et al, (2005), Transplantation, 79, 38 - 43

• The ratio between class II and class I collagenase determines the amount of neutral protease activity required for efficient islet release from the rat pancreas.

  Journal article

  Brandhorst H. et al, (2005), Transplant Proc, 37, 215 - 216

• Timing of hyperthermic preconditioning affects islet resistance against inflammation.

  Journal article

  Brandhorst D. et al, (2005), Transplant Proc, 37, 231 - 232

• Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.

  Journal article

  Brandhorst D. et al, (2005), Transplant Proc, 37, 229 - 230

• Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.

  Journal article

  Brandhorst D. et al, (2005), Transplant Proc, 37, 458 - 459

• Influence of neutral protease activity on human islet isolation outcome.

  Journal article

  Brandhorst H. et al, (2005), Transplant Proc, 37, 241 - 242

• Can the density of native pancreatic tissue slices predict human islet isolation and purification outcome?

  Journal article

  Eckhard M. et al, (2004), Transplant Proc, 36, 2845 - 2848

• Optimization in osmolality and range of density of a continuous ficoll-sodium-diatrizoate gradient for isopycnic purification of isolated human islets.

  Journal article

  Eckhard M. et al, (2004), Transplant Proc, 36, 2849 - 2854

• Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes.

  Journal article

  Bränström R. et al, (2004), Diabetologia, 47, 277 - 283

• Islet cell transplantation - Current state and perspectives

  Journal article

  Brendel MD. et al, (2003), Diabetes und Stoffwechsel, 12, 239 - 252

• Pretreatment of isolated islets with caspase-3 inhibitor DEVD increases graft survival after xenotransplantation.

  Journal article

  Brandhorst H. et al, (2003), Transplant Proc, 35

• Heat-exposed pig islets are protected from inflammatory mediators but express proapoptotic proteins.

  Journal article

  Brandhorst D. et al, (2003), Transplant Proc, 35

• Successful human islet isolation utilizing recombinant collagenase.

  Journal article

  Brandhorst H. et al, (2003), Diabetes, 52, 1143 - 1146

• Angiogenic capacity of endothelial cells in islets of Langerhans.

  Journal article

  Linn T. et al, (2003), FASEB J, 17, 881 - 883

• [Apoptosis induced by free fatty acids].

  Journal article

  Eitel K. et al, (2003), Med Klin (Munich), 98, 248 - 252

• Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.

  Journal article

  Eitel K. et al, (2003), Diabetes, 52, 991 - 997

• Hyperthermic preconditioning protects pig islet grafts from early inflammation but enhances rejection in immunocompetent mice.

  Journal article

  Brandhorst D. et al, (2003), Cell Transplant, 12, 859 - 865

• High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.

  Journal article

  Brandhorst D. et al, (2002), Transplantation, 73, 74 - 79

• Metabolic effects of restoring partial beta-cell function after islet allotransplantation in type 1 diabetic patients.

  Journal article

  Luzi L. et al, (2001), Diabetes, 50, 277 - 282

• Prevention of intraportal islet failure by a highly selective iNOS inhibitor in the pig-to-nude rat model.

  Journal article

  Brandhorst D. et al, (2001), Transplant Proc, 33

• Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.

  Journal article

  Brandhorst D. et al, (2001), Transplantation, 71, 179 - 184

• Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival.

  Journal article

  Brandhorst D. et al, (2000), Cell Transplant, 9, 423 - 430

Recent Publications

• Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.

  Journal article

  Brandhorst D. et al, (2013), Apoptosis, 18, 681 - 688

• Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

  Journal article

  Brandhorst H. et al, (2013), Cell Transplant, 22, 1477 - 1483

• Oxygen-charged HTK-F6H8 emulsion reduces ischemia-reperfusion injury in kidneys from brain-dead pigs.

  Journal article

  Asif S. et al, (2012), J Surg Res, 178, 959 - 967

• Oxygen-charged HTK-F6H8 emulsion reduces ischemia-reperfusion injury in kidneys from brain-dead pigs

  Journal article

  Asif S. et al, (2012), Journal of Surgical Research, 178, 959 - 967

• Using HTK for prolonged pancreas preservation prior to human islet isolation.

  Journal article

  Caballero-Corbalán J. et al, (2012), J Surg Res, 175, 163 - 168