Contact information
Research groups
Research Interests
Interventional Oncology
Thermal Tumour Ablation
Therapeutic Ultrasound
Targeted Drug Delivery
High Intensity Focused Ultrasound
Immunomodulation
Bioinformatics
Paul Lyon
FRCR, DPhil, MRes, MSc, BSc, PGDip
Senior Research Fellow in Interventional Oncology
- Consultant Radiologist (Oxford Thermal Ablation Team)
- Associate Clinical Director of HIFU, Churchill Hospital
Dr Lyon holds a part-time Senior Clinical Research Fellowship with the Nuffield Department of Surgical Sciences, working in close collaboration with the Institute of Biomedical Engineering at the University of Oxford to develop and deliver clinical trials in Therapeutic Ultrasound.
He has over ten years of pre-clinical and clinical experience in Therapeutic Ultrasound and its clinical application, steming from his DPhil in which he delivered the first clinical trial to demonstrate safety and efficacy of the use of focused ultrasound to facilitate targeted drug delivery to solid tumours in man (TARDOX Study, Lancet Oncology). Dr Lyon has authored or co-authored over 20 peer reviewed clinical papers, over half of which concerning Therapeutic Ultrasound.
Dr Lyon is also a Clinical Radiologist who performs minimally-invasive and non-invasive image-guided tumour ablation procedures (Microwave, Cryoablation, Therapeutic Ultrasound) for NHS cancer patients at the Churchill Hospital, Oxford University Hospitals NHS Foundation Trust. He is the Associate Clinical Director for the High Intensity Focused Ultrasound (HIFU) Unit in Oxford and co-director of the Focused Ultrasound Foundation Centre of Excellence.
Recent publications
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Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound.
Spiers L. et al, (2023), BMC Cancer, 23
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Immune checkpoint inhibition: a future guided by radiology.
Khan F. et al, (2023), Br J Radiol, 96
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A rare case of disseminated genitourinary tract tuberculosis complicated by emphysematous prostatitis and seminal vesicle abscess.
Kundasamy P. et al, (2023), BJR Case Rep, 9
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Hyperacute Phase Catecholamingergic Polymorphic Ventricular Tachycardia Captured on Computed Tomography
Turlejski T. et al, (2023), Cardiovascular Imaging Asia, 7, 32 - 32
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A bump in the night: a 15-year retrospective analysis of urgent inpatient and emergency CT reporting out of hours in a tertiary referral centre.
Lyon PC. et al, (2022), Clin Radiol