Research groups
Contact information
Paul Lyon
BSc, MSc, MRes, BMBS, MRCS, DPhil
Clinical Research Fellow
- High Intensity Focused Ultrasound (HIFU) Fellow
- Keble College Tutor (2014-2015)
- Academic Clinical Fellow in Radiology
I am currently in post as an Academic Clinical Fellow in Radiology. This follows time in research as a NIHR-funded Clinical Research Fellow studying for a DPhil in targeted drug delivery. More specifically, my research concerns the use of focused ultrasound (HIFU) for targeted drug delivery and its clinical translation. I am involved in conducting a Phase I clinical trial, which aims to demonstrate the feasibility of using a clinical HIFU device in combination with a thermo-sensitive drug delivery system to deliver targeted chemotherapy to cancer patients with liver tumours (TARDOX study, NCT02181075). The study is multidisciplinary and I have been involved in many aspects including trial design, ethics and trial management, analytical laboratory techniques, use of focused ultrasound for hyperthermia and radiological imaging, with the world-class research facilities and expertise available within the University of Oxford and Oxford University Hospitals NHS Trust.
This study has the potential for significant clinical impact as, if feasibility of targeted drug delivery using this modality can be successfully demonstrated for liver tumours, following further clinical trials, non-invasive targeted therapy using tailored chemotherapeutics for a variety of solid organ cancers could become a reality.
Recent publications
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A rare case of disseminated genitourinary tract tuberculosis complicated by emphysematous prostatitis and seminal vesicle abscess.
Journal article
Kundasamy P. et al, (2023), BJR Case Rep, 9
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A bump in the night: a 15-year retrospective analysis of urgent inpatient and emergency CT reporting out of hours in a tertiary referral centre.
Journal article
Lyon PC. et al, (2022), Clin Radiol
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Large-Volume Hyperthermia for Safe and Cost-Effective Targeted Drug Delivery Using a Clinical Ultrasound-Guided Focused Ultrasound Device.
Journal article
Lyon PC. et al, (2021), Ultrasound Med Biol, 47, 982 - 997
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Quantifying cell death induced by doxorubicin, hyperthermia or HIFU ablation with flow cytometry.
Journal article
Lyon PC. et al, (2021), Sci Rep, 11
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Ultrasound-Guided High Intensity Focused Ultrasound Ablation for Symptomatic Uterine Fibroids: Preliminary Clinical Experience.
Journal article
Lyon PC. et al, (2020), Ultraschall Med, 41, 550 - 556