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Research Interests

Interventional Oncology

Thermal Tumour Ablation

Therapeutic Ultrasound

Targeted Drug Delivery

High Intensity Focused Ultrasound



Paul Lyon

FRCR, DPhil, MRes, MSc, BSc, PGDip

Senior Research Fellow in Interventional Oncology

  • Consultant Radiologist (Oxford Thermal Ablation Team)
  • Associate Clinical Director of HIFU, Churchill Hospital

Dr Lyon holds a part-time Senior Clinical Research Fellowship with the Nuffield Department of Surgical Sciences, working in close collaboration with the Institute of Biomedical Engineering at the University of Oxford to develop and deliver clinical trials in Therapeutic Ultrasound.

He has over ten years of pre-clinical and clinical experience in Therapeutic Ultrasound and its clinical application, steming from his DPhil in which he delivered the first clinical trial to demonstrate safety and efficacy of the use of focused ultrasound to facilitate targeted drug delivery to solid tumours in man (TARDOX Study, Lancet Oncology). Dr Lyon has authored or co-authored over 20 peer reviewed clinical papers, around half of which concerning Therapeutic Ultrasound.

Dr Lyon is also a Clinical Radiologist who performs mimimally-invasive and non-invasive image-guided tumour ablation procedures (Microwave, Cryoablation, Therapeutic Ultrasound) for NHS cancer patients at the Churchill Hospital, Oxford University Hospitals NHS Foundation Trust. He is the Associate Clinical Director for the High Intensity Focused Ultrasound (HIFU) Unit in Oxford.