Metastasis of cancers to bone
Cancer-induced bone disease is a characteristic feature of several types of cancer, including the hematological malignancy multiple myeloma, and other tumors that metastasise to bone such as breast, prostate and lung. In addition to the development of debilitating skeletal complications, the bone marrow provides a unique hospitable microenvironment, and once tumors become established in bone, they are largely unresponsive to treatment.
The overall goal of our research is to elucidate the cellular and molecular mechanisms that contribute to disease pathogenesis, and so identify and validate novel therapeutic approaches. Our focus is on the role of the tumor microenvironment and tumor-host interactions.