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Tibia from control (left) and myeloma-bearing (right) mice, with osteoclast activity stained red. Copyright: Edwards Group 2013
Tibia from control (left) and myeloma-bearing (right) mice, with osteoclast activity stained red.

Cancer-induced bone disease is a characteristic feature of several types of cancer, including the hematological malignancy multiple myeloma, and other tumors that metastasise to bone such as breast, prostate and lung. In addition to the development of debilitating skeletal complications, the bone marrow provides a unique hospitable microenvironment, and once tumors become established in bone, they are largely unresponsive to treatment.

The overall goal of our research is to elucidate the cellular and molecular mechanisms that contribute to disease pathogenesis, and so identify and validate novel therapeutic approaches. Our focus is on the role of the tumor microenvironment and tumor-host interactions.

Selected publications

Grant Support

Collaborators

Professor Freddie Hamdy

Dr Richard Bryant

Dr James Edwards

Professor Nick Athanasou

Dr Conor Lynch (Moffit Cancer Center, Florida, USA)

Dr Matthew Drake (Mayo Clinic, Rochester, USA)

Dr Florent Elefteriou (Vanderbilt University, Nashville, USA)

Research Projects

Related research themes