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Professors Valentine Macaulay and Ian Mills from the Nuffield Department of Surgical Sciences (NDS) are among the awardees of the 2021 round of the CRUK Oxford Centre Development Fund.

Development Fund logo

14 projects have been selected by the CRUK Oxford Centre to receive pump-priming funds. This unique scheme aims to support collaborative projects in cancer research which are a key area of activity for the Centre.

Professor Macaulay, Professor Mills and Jack Mills, an Oncology DPhil candidate in the Macaulay Lab, have been awarded a Development Fund for their research into 'Investigating nuclear IGF-1R function in clinical prostate cancers'.

Insulin-like growth factors (IGFs) play key roles in prostate cancer biology. Type 1 IGF receptors (IGF-1Rs) are up-regulated in primary cancer and associated with lethal castrate-resistant prostate cancer (CRPC). This project aims to understand how nuclear IGF-1R regulates expression of genes contributing to cancer cell growth, androgen response and therapy resistance in vivo.

See a summary of all the awardees and their projects on the Oxford Cancer website.

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