Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Professors Valentine Macaulay and Ian Mills from the Nuffield Department of Surgical Sciences (NDS) are among the awardees of the 2021 round of the CRUK Oxford Centre Development Fund.

Development Fund logo

14 projects have been selected by the CRUK Oxford Centre to receive pump-priming funds. This unique scheme aims to support collaborative projects in cancer research which are a key area of activity for the Centre.

Professor Macaulay, Professor Mills and Jack Mills, an Oncology DPhil candidate in the Macaulay Lab, have been awarded a Development Fund for their research into 'Investigating nuclear IGF-1R function in clinical prostate cancers'.

Insulin-like growth factors (IGFs) play key roles in prostate cancer biology. Type 1 IGF receptors (IGF-1Rs) are up-regulated in primary cancer and associated with lethal castrate-resistant prostate cancer (CRPC). This project aims to understand how nuclear IGF-1R regulates expression of genes contributing to cancer cell growth, androgen response and therapy resistance in vivo.

See a summary of all the awardees and their projects on the Oxford Cancer website.

Similar stories

Another successful year for SITU NDS

The Surgical Intervention Trials Unit in the Nuffield Department of Surgical Sciences (SITU NDS) has had another successful year, now running ten randomised controlled trials across surgical specialties and securing a total of £32 million in current peer-reviewed grants.

NDS projects awarded CRUK Oxford Cancer Development Fund

Two research projects at the Nuffield Department of Surgical Sciences (NDS) have been awarded pump-prime funding from this year’s CRUK Oxford Centre Development Fund.

DPhil student awarded prestigious prize by Italian medical academy

This year’s winner of the prestigious Giovanni Maria Lancisi Award is Dr Pierfrancesco Lapolla Losasso, DPhil candidate at Nuffield Department of Surgical Sciences (NDS), presenting the research project 'Combined physiological and biochemical approach for the prediction of abdominal aortic aneurysm growth in humans' conducted through the OxAAA study.

Study finds higher risk of all-cause mortality among paediatric cancer patients in LMICs during the pandemic

During the first nine months of the COVID-19 pandemic, paediatric cancer patients from lower- and middle-income countries (LMICs) faced a higher risk of all-cause mortality than those in high-income countries, according to an international study led by the University of Oxford.

Athena Swan Silver Award renewal for NDS

We're delighted to announce that we have been successful in the renewal of our Athena Swan Silver Award, recognising our work in advancing gender equality.

Study reveals that bone changes energy requirements of cancer cells to promote growth and survival

Interrogating metabolic cross-talk in the tumour-bone microenvironment, new research from the Edwards Group shows how the pentose phosphate pathway contributes to prostate cancer bone metastasis.

Blog posts

Lights, camera, action! My journey into video production

Dr Hannah McGivern provides a 'behind-the-scenes' account of her experience producing the video 'Journey of a QUOD Sample: Donating to Transplant Research', supported by the funds from the University of Oxford Public Engagement with Research (PER) Seed Fund.

Mentoring in practice

NDS has launched a new, interdepartmental mentoring scheme called RECOGNISE. In this podcast, Gemma Horbatowski (HR Advisor) interviews Monica Dolton (Programme Manager and Research Project Manager) about her experiences of mentor-mentee relationships.

Wrap up of 2021

After a brilliant year of hard work and dedication, the SITU team has done some reflection on 2021, focusing on key events, trial progression, and more. Read on to discover how the year 2021 went for the SITU team...

Celebrating Anti-Bullying Week with words of kindness

Keeva Heap, who is undertaking a communications work experience placement at the Nuffield Department of Surgical Sciences (NDS), shares our words of kindness In honour of Anti-Bullying Week.

My virtual work experience with NDS and NDORMS

Louise Tan, a Year 12 student from Ballyclare in County Antrim, Northern Ireland, recently attended the joint NDS and NDORMS Virtual Work Experience. In this guest blog, Louise reflects on her experience.