Contact information
LOCATION
Radiobiology Research Institute, Churchill Hospital, Headington, Oxford
Research groups
Collaborators
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Clare Verrill
Associate Professor
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Ian Mills
John Black Associate Professor of Prostate Cancer and Deputy Head of Department
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Freddie Hamdy
Head of Department
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Alastair Lamb
Cancer Research UK Clinician Scientist
Valentine Macaulay
MD, PhD, FRCP
Emeritus Associate Professor
- Honorary Consultant in Medical Oncology
I qualified as a doctor at Charing Cross Hospital Medical School and trained in Medical Oncology at the Royal Marsden Hospital London and Churchill Hospital Oxford. Following a PhD with Alan Ashworth at Chester Beatty Laboratories in London, my postdoctoral training was supported by MRC Clinician Scientist and Cancer Research UK Senior Clinical Fellowships and HEFCE Clinical Senior Lectureship. I was Associate Professor and Honorary Consultant in Medical Oncology, Department of Oncology, University of Oxford from 2001 to 2021, now Emeritus Associate Professor, Nuffield Department of Surgical Sciences, University of Oxford. My laboratory research group uses basic, translational and clinical research to investigate the role of IGFs in prostate cancer and is supported by collaborating clinicians and scientists in Oxford and elsewhere.
Recent publications
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CHK1 inhibition exacerbates replication stress induced by IGF blockade
Journal article
Macaulay V. et al, (2021), Oncogene
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IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits.
Journal article
Mills JV. et al, (2021), Discov Oncol, 12
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IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits
Journal article
Mills JV. et al, (2021), Discover Oncology
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Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction.
Journal article
Rieunier G. et al, (2021), Cancer Res, 81, 2128 - 2141
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IGF targeting perturbs global replication through ribonucleotide reductase dysfunction.
Working paper
RIEUNIER G. et al, (2020), BioRxiv