Oxford Prostate Cancer Biology Group
The Prostate Cancer Biology Group focusses on metabolic pathways, spatial clonal biology, and developing multiplexed models to facilitate more accurate study of prostate cancer lethality.
Prostate cancer emerges from the cross-talk between genomic alterations, metabolic dysregulation and adaptive changes in the tumour micro-environment. In metastatic disease some genomic drivers have been identified but in order to more effectively risk stratify localised disease and treat high-risk disease effectively, it is important to fully characterise at a cellular and molecular level. As a translational lab comprising basic scientists and clinician scientists, we are addressing this challenge using spatial methods and clinical material to refine the pre-clinical models and target pathways that we focus on scientifically. Many of these pathways are regarded as enabling biologies, supporting cell survival under metabolic and oncogenic stress. Examples include the unfolded protein response and glycosylation. Our work on patient samples focuses on the in-depth profiling of small numbers of patient samples and we exemplify and validate our findings by participating in multi-institutional consortia (e.g., PPCG) and utilising large cohorts with long-term follow-up.
Areas of Research
Metabolic pathways and the unfolded protein response
Spatial clonal biology
Glycosylation and OGlcNAc transferase
PhenoCycler Multiplex Imaging
We welcome enquiries regarding our programme of work and possible positions in the group.
Our work is supported by grants from the Rosetrees Trust, CRIS Cancer Foundation, Larry Leeds, Eustace Wolfington, John Black Charitable Foundation, Cancer Research UK, Prostate Cancer UK, The Hanson Research Trust and the Prostate Cancer Foundation.
Richard Bryant (NDS)
Jason Davis (Chemistry)
Claire Edwards (NDORMS/NDS)
Val Macaulay (NDS)
Eileen Parkes (Oncology)
Jens Rittscher (NDM)
Chunxiao Song (Ludwig)
Dan Woodcock (NDS)
Andrea Alimonti (Bellinzona)
Lisa Butler (Adelaide)
Harri Itkonen (Helsinki)
Clementine Le Magnen (Basel)
Joakim Lundeberg (Stockholm)
Tuomas Mirrti (Helsinki)
Pete Nelson (Seattle)
Alfonso Urbanucci (Oslo)
Dimitrios Doultsinos wins Young Investigator Award from the Prostate Cancer Foundation
10 November 2022
Dr Dimitrios Doultsinos, a John Black Research Fellow in Prostate Oncology at Oxford University's Nuffield Department of Surgical Sciences (NDS), was one of this year’s recipients of the highly coveted Prostate Cancer Foundation (PCF) Young Investigator Award.
Genetic mapping of tumours reveals how cancers grow
11 August 2022
Researchers from the University of Oxford, KTH Royal Institute of Technology, Science for Life Laboratory, and the Karolinska Institutet, Solna, Sweden, have found that individual prostate tumours contain a previously unknown range of genetic variation.