LOCATION
Botnar Research Centre, Old Road, Headington, Oxford OX3 7LD
Research groups
Colleges
Claire Edwards
Associate Professor of Bone Oncology
- Director of Graduate Studies for NDS
Associate Professor Claire Edwards (née Shipman) obtained a first class honours degree and Ph.D. from the University of Sheffield, where she began her career in cancer-induced bone disease.
Following postdoctoral studies at the University of Sheffield and the University of Oxford, Associate Professor Edwards moved to the United States in 2004 to take up assistant professor positions at the University of Texas Health Science Center at San Antonio and subsequently at Vanderbilt University.
Associate Professor Edwards is the recipient of multiple awards and fellowships, including most recently, the Iain T. Boyle Award from the European Calcified Tissue Society.
Associate Professor Edwards has recently relocated her lab to the University of Oxford as a University Lecturer in Bone Oncology, with a joint appointment in the Nuffield Department of Surgical Sciences (NDS) and the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), and a fellowship at St. Edmund Hall.
Research interests are focused upon the pathogenesis of cancer-induced bone disease, including the contributions of the host bone marrow microenvironment and the role of obesity, adipocytes and adipokines.
Websites
Key publications
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Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival.
Journal article
Whitburn J. et al, (2022), Sci Adv, 8
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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Journal article
Gooding S. et al, (2019), Nat Commun, 10
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Myeloma cells down-regulate adiponectin in bone marrow adipocytes via TNF-alpha.
Journal article
Morris EV. et al, (2019), J Bone Miner Res
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Diet-induced obesity promotes a myeloma-like condition in vivo.
Journal article
Lwin ST. et al, (2015), Leukemia, 29, 507 - 510
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Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer.
Journal article
Rao SR. et al, (2017), Br J Cancer, 116, 227 - 236
Recent publications
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Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Journal article
Richter FC. et al, (2023), EMBO J
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Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.
Journal article
Leng H. et al, (2022), Nat Commun, 13
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Multiple myeloma metabolism – a treasure trove of therapeutic targets?
Journal article
Roman-Trufero M. et al, (2022), Frontiers in Immunology, 13
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Editorial - Cancer and Bone special issue.
Journal article
Edwards CM. and Drake MT., (2022), Bone, 158
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Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival.
Journal article
Whitburn J. et al, (2022), Sci Adv, 8