John Radcliffe Hospital, Level 5 and 6, Headley Way, Headington, Oxford, OX3 9DU
DPHIL START DATE
An exploration of post-transplantation γδ T cell phenotype and function
BMBS, PGDip, AKC, MRCS.
DPhil candidate and Clinical Research Fellow
- Clinical Teaching Associate – Exeter College
Generating a granular description of immunological rejection following transplantation is key to developing novel immunosuppressive strategies. During my DPhil I aim to characterise where a subset of unconventional lymphocytes—γδ T cells—are mechanistically situated in transplant rejection in order to modulate their cascade through targeted intervention. γδ T cells are of particular interest in this setting due to their MHC-unrestricted recognition of antigen, promulgation of damaging downstream immune responses, and functional heterogeneity. I plan to use several techniques during my DPhil including in vitro assays, bulk and single cell NGS, and in situ transcriptomics to longitudinally describe the γδ T cell compartment following kidney transplantation. My work is generously supported by both a Medical Research Council Clinical Research Training Fellowship, and a Royal College of Surgeons Research Fellowship.
Alongside my research I enjoy medical education. I currently work as a Clinical Teaching Associate at Exeter College providing tutorials for medical students, am a divisional examiner for Medical Sciences at the Oxford Learning Centre, and give regular seminars and laboratory workshops in anatomy and paediatrics. I have supervised small undergraduate and masters-level projects in the past, many of which have gone on to be presented or published, and am always very happy to be emailed to discuss collaboration or supervision requests.
Distinct metabolic pathways mediate regulatory T cell differentiation and function.
Hashimoto H. et al, (2020), Immunol Lett, 223, 53 - 61
Infantile virilisation caused by an androstenedione-producing adrenal adenoma
McCallion O. et al, (2019), Journal of Pediatric Surgery Case Reports, 48
Primary Surgical Resection versus Intralesional Sclerosant Therapy for Paediatric Congenital Lymphatic Malformations: An International, Multi-Centre Cohort Study
McCallion O. et al, (2019), BRITISH JOURNAL OF SURGERY, 106, 114 - 114
Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation.
McCallion O. et al, (2018), Transplantation, 102, 1983 - 1993
Music models aberrant rule decoding and reward valuation in dementia.
Clark CN. et al, (2018), Soc Cogn Affect Neurosci, 13, 192 - 202