Collaborators
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Simon Buczacki
Richard Blackwell Pharsalia Professor of Colorectal Surgery, Cancer Sciences Theme Lead
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Peter Friend
Emeritus Professor of Transplantation
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Hussain Abbas
DPhil Student and Clinical Research Fellow in Transplant Surgery
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Fungai Dengu
Academic Clinical Lecturer in Transplant Surgery
Research groups
Alex Gordon-Weeks
MBChB, BSc, DPhil, FRCS
Consultant Hepatobiliary Surgeon and Clinical Lecturer
- Surgical Specialty Lead for Colorectal Liver Metastase, Royal College of Surgeons of England
Liver Cancer Biology Group
Research Interests
Spatial biology of primary and metastatic liver cancers.
Hemi-liver perfusion as a novel liver cancer model.
Radiomics for cancer prognostication.
Regulation of tumour immunity.
Clinical Interests
I work as an NHS surgeon within the University of Oxford Hospitals NHS Foundation Trust. I chair the advanced liver cancer multidisciplinary team meeting held at the Churchill Hospital site. The focus of my practice is malignant and benign hepatobiliary pathology inclusive of:
Primary and metastatic liver cancers.
Pancreatic cancer.
Cholangiocarcinoma.
Awards
2025 CRUK Discovery Programme Award
2022 CRUK Oxford Cancer Development Fund
Key publications
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Journal article
Im JH. et al, (2020), Nat Commun, 11
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Journal article
Yuzhalin AE. et al, (2018), Nat Commun, 9
Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice.
Journal article
Gordon-Weeks AN. et al, (2017), Hepatology, 65, 1920 - 1935