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My connections

Biography

I completed my undergraduate education at the Universities of Nottingham and Warwick and continued my training in the West Midlands. I have taken time out of higher surgical training to complete a DPhil as Royal College of Surgeons Research Fellow at the Nuffield Department of Surgical Sciences. My main academic interest is in pancreas transplantation and my clinical interest is in transplant and endocrine surgery.

James Barnes

BSc, MBChB, MRCS


Clinical Research Fellow and DPhil student

My main research interest is in pancreas transplantation with a focus on graft surveillance after transplantation.

Pancreas transplantation is a well established and highly effective therapy for some patients with the most severe complications of diabetes. However, there is a problem with medium term graft loss which we believe is due to the absence of a clinically useful marker of graft injury. Therefore, I am investigating ways of identifying graft dysfunction earlier than is currently possible through improved assessment and monitoring of graft function. This needs to remain clinically relevant and applicable to our patients who frequently live many hours away from the transplant centre.

It is thought that the main cause of graft failure is predominantly rejection and therefore we need an effective and robust immune monitoring system. I am investigating the use of donor derived skin that is transplanted at the same time as the pancreas. This may provide a visual barometer of rejection that can be easily and painlessly biopsied. Alongside the clinical pilot study we are performing cellular and molecular analyses to identify sensitive markers that predict skin and pancreas rejection

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