Contact information
Research groups
Research Interests
Interventional Oncology
Thermal Tumour Ablation
Therapeutic Ultrasound
Targeted Drug Delivery
High Intensity Focused Ultrasound
Immunomodulation
Bioinformatics
Paul Lyon
FRCR, DPhil, MRes, MSc, BSc, PGDip
Senior Research Fellow in Interventional Oncology
- Consultant Radiologist (Oxford Thermal Ablation Team)
- Associate Clinical Director of HIFU, Churchill Hospital
Dr Lyon holds a part-time Senior Clinical Research Fellowship with the Nuffield Department of Surgical Sciences, working in close collaboration with the Institute of Biomedical Engineering at the University of Oxford to develop and deliver clinical trials in Therapeutic Ultrasound.
He has over ten years of pre-clinical and clinical experience in Therapeutic Ultrasound and its clinical application, steming from his DPhil in which he delivered the first clinical trial to demonstrate safety and efficacy of the use of focused ultrasound to facilitate targeted drug delivery to solid tumours in man (TARDOX Study, Lancet Oncology). Dr Lyon has authored or co-authored over 20 peer reviewed clinical papers, over half of which concerning Therapeutic Ultrasound.
Dr Lyon is also a Clinical Radiologist who performs minimally-invasive and non-invasive image-guided tumour ablation procedures (Microwave, Cryoablation, Therapeutic Ultrasound) for NHS cancer patients at the Churchill Hospital, Oxford University Hospitals NHS Foundation Trust. He is the Associate Clinical Director for the High Intensity Focused Ultrasound (HIFU) Unit in Oxford and co-director of the Focused Ultrasound Foundation Centre of Excellence.
Recent publications
Safety and efficacy of microwave ablation of lung tumours close to the heart and aorta.
Journal article
Li Y-L. et al, (2026), Clin Radiol, 95
Imaging and intervention for soft tissue tumours in the era of locoregional therapies and immunotherapy.
Journal article
Rehman S. et al, (2025), Clin Radiol, 87
High-intensity focused ultrasound treatment of unresectable soft tissue sarcoma and desmoid tumours - a systematic review.
Journal article
Chetan M. et al, (2025), Clin Radiol, 87
No turning back: a long-term retrospective analysis of urgent magnetic resonance imaging (MRI) performed for suspected cauda equina compression in a tertiary referral centre.
Journal article
Stoddart C. et al, (2025), Clin Radiol, 86
Salvage Glue Embolization of Iatrogenic Alveolar-Pleural Fistula Following Lung Ablation
Journal article
Li Y-L. et al, (2024), Journal of Clinical Interventional Radiology ISVIR, 08, 181 - 183