Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A multi-disciplinary team led by the Transplantation Research Immunology Group (TRIG) in the University of Oxford’s Nuffield Department of Surgical Sciences has been awarded a grant of c£2.5m from the Medical Research Council to undertake a pioneering clinical trial of cellular therapy in renal transplantation.

The TWO Study aims to assess the feasibility of reducing immunosuppression in renal transplant recipients with the use of regulatory T cells (Treg). The trial will be led by the University of Oxford’s Dr Fadi Issa (PI), Dr Paul Harden (Co-PI & Clinical Lead), Professor Peter Friend (Chief Investigator) and Dr Joanna Hester (Immune Biology Lead), together with Professor Giovanna Lombardi of King’s College London, senior researchers from TRIG, the Oxford Transplant Centre, the University’s Surgical Trials Intervention Unit, Oxford University Innovation, and the BRC GMP facility at Guy’s and St Thomas’ NHS Foundation Trust.

The trial aims to recruit 68 patients over a three-year period, with those receiving the cellular therapy donating a unit of blood for isolation of Tregs. Isolated Treg will then be expanded in a purpose-built GMP facility at Guy's Hospital in London. The function of kidney transplants will be assessed and the amount of drug-based immunosuppression reduced accordingly. Patients will be closely monitored and potential early markers of improved immune function will be determined using advanced assessment techniques.

For more information about the project please contact Monica Dolton, the Project Manager.

Similar stories

Clare Verrill receives Turing Fellowship

Thirty-three University of Oxford researchers have been named Turing Fellows for the 2021/22 academic year, including Associate Professor Clare Verrill from the Nuffield Department of Surgical Sciences (NDS).

Researchers awarded Wellcome Innovator Grant to investigate role of brainstem nucleus in human consciousness

Researchers at Oxford University have received a prestigious Wellcome Innovator Grant for investigating the role of the pedunculopontine nucleus (PPN) – a brainstem nucleus – in human consciousness.

Discovered gene patterns can predict prostate cancer treatment response

Nearly 40,000 men are diagnosed with prostate cancer each year in the UK. Perhaps the most significant clinical challenge today is deciding which type of treatment will work best for different patient groups.

Regent Lee wins top UKRI Future Leaders Fellowship

Dr Regent Lee of the Nuffield Department of Surgical Sciences is one of eight Oxford University academics who have been awarded significant financial funding from the UK Research and Innovation’s (UKRI) Future Leaders Fellowships Scheme.

Largest trial of carotid artery surgery and stenting finds similar long-term effects on stroke risk

Results from a major clinical trial demonstrate that both stenting and surgery are low-risk and similarly effective procedures for treating carotid artery disease.

Blog posts

My virtual work experience with NDS and NDORMS

Louise Tan, a Year 12 student from Ballyclare in County Antrim, Northern Ireland, recently attended the joint NDS and NDORMS Virtual Work Experience. In this guest blog, Louise reflects on her experience.

Celebrating women of NDS

To celebrate 100 years since women were admitted as full members of the University and on the occasion of International Women's Day, a group of inspirational women in the Nuffield Department of Surgical Sciences (NDS) reflect on their journeys, their place in Medical Sciences and their vision for the next 100 years.

The life of a research nurse: supporting the Oxford COVID-19 Vaccine Trial

Research nurses in the NHS are playing a crucial role in helping to trial new coronavirus treatments and vaccines. Three NDS research nurses stepped up to help with the fight against this new disease. Here Bhumika Patel shares her experience of working on the Oxford COVID-19 Vaccine Trial.

Why I became a Peer Supporter

The Peer Support Programme was developed in recognition of the essential role students play in supporting and encouraging one another on a day-to-day basis throughout their time at university. NDS’ own Helen Stark discusses her experience of becoming a Peer Supporter.

Racism under the microscope

As Black History Month gets underway in the UK, NDS Athena SWAN Coordinator Emily Hotine puts racism under the microscope.