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The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1--the tissue kallikrein--and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins is inadequate or insufficient. Here we present a new nomenclature in which proteins without proven kininogenase activity are denoted kallikrein-related peptidase. Names are also given to the unique rodent proteins that are closely related to kallikrein 1.

Original publication

DOI

10.1515/BC.2006.082

Type

Journal article

Journal

Biol Chem

Publication Date

06/2006

Volume

387

Pages

637 - 641

Keywords

Chromosomes, Human, Pair 19, Humans, Sequence Homology, Serine Endopeptidases, Terminology as Topic, Tissue Kallikreins