Location

Oxford Blood Donor Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ

Rutger J. Ploeg, Professor of Transplant Biology and Head of Strategy

Peter Friend, Professor of Transplantation

Fadi Issa, Professor of Transplantation

Benedikt Kessler, Professor of Biochemistry and Mass Spectrometry

Edward Sharples, Oxford Hospitals NHS Trust, Consultant Renal Medicine

Chris Sutton, University of Bradford, Professor of Biochemistry and Mass Spectrometry

Richard Telford, University of Bradford, Professor of Analytical Chemistry

Jan Lindeman, Leiden University, Netherlands, Professor of Vascular Surgery

My research bridges cutting‑edge molecular science and clinical medicine to uncover the biological signals that drive outcomes in solid organ transplantation and cancer. My research integrates proteomics, metabolomics, genomics, and pharmacokinetics to uncover molecular insights that guide clinical decision-making.

I develop and implement high-resolution analytical workflows to study a range of biological samples, including tissue, plasma, urine, bile, and perfusate. Current research focuses on:

• Identifying molecular signatures associated with diagnosis, prognosis, and transplant outcomes
• Investigating molecular recipient factors (e.g., dialysis, diabetes) in kidney transplantation
• Profiling post‑translational modifications (PTMs) such as carbamylation, phosphorylation, and oxidation as biomarkers of cellular ageing, inflammation, senescence, and cancer progression

Alongside my research, I manage the Proteomics and Metabolomics Facility, providing:

• Mass spectrometry-based clinical proteomics, metabolomics, and pharmacokinetics
• Biomarker discovery and multi-omics data integration
• Study design consultation for clinical omics research
• Bioinformatics support, data analysis, and training workshops for researchers

I have received research funding as Principal Investigator and Co-Investigator from major organisations including Kidney Research UK, NHS Blood and Transplant, NIHR, European Commission, and the Oxford Transplant Foundation. I also serve as an investigator on national and international clinical trials, providing molecular profiling and biomarker strategy expertise.