B-Pharm, MSc Oncology, PhD
Translational Omics Scientist
I am Translational Omics Scientist within the Transplantation Research Group in the Nuffield Department of Surgical Sciences at the University of Oxford. My work focuses on the identification of new diagnostic and prognostic biomarkers of organ injury and repair in solid organ transplantation. We have developed novels methods to generate Multi-Omics data from a range of biological materials: tissues, blood, urine, tears, saliva, nipple aspirate fluid (NAF), bile and organ perfusate, within the Consortium on Organ Preservation in Europe (COPE) and the Consortium on Quality in Organ Donation (QUOD) in the UK. The profiling for Proteins and Metabolites will enable (i) the selection of viable organs for transplantation, (ii) the elucidation of the molecular pathways involved in the onset of ischemia and repair, and (iii) identification of optimal interventions in perfusion models to reduce organ damage during the transplantation process.
After completing my Bachelor of Pharmacy from Bahauddin Zakariya University, Pakistan, I did my MSc in Oncology at University of Bradford UK in 2011. I worked as Research Technician in Proteomics at University of Bradford for 2 years and was involved in maintenance and development of LC-MS methods for identification of biomarkers in human cancers. In 2017, I completed my PhD degree under supervision of Prof. Laurence H. Patterson and Dr. Chris W. Sutton at Institute of Cancer Therapeutics, University of Bradford, UK, focused on early detection and stratification of breast cancer subtypes using Proteomics applications. From 2017 to 2019, I was involved in a Drug development Programme funded by Yorkshire Cancer Research UK. In 2019, I moved to Cancer Research UK Cambridge Institute and was involved in Management and maintenance of Proteomics facility and developed new methods for proteins analysis. In 2020, I was appointed as Translational Omics Scientist in the Nuffield Department of Surgical Sciences at the University of Oxford UK.
“Proteomics analysis of colon cancer progression”, Saira Saleem, Sahrish Tariq, Iffat Aleem, Sadr ul Shaheed, Muhammad Tahseen, Aribah Atiq, Chris Sutton, Clinical proteomics 2019, 16:44
“Evaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer”, Sadr ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab, Chris Sutton, Clinical proteomics 2018, 1559-0275.
“Nipple aspirate fluid - a liquid biopsy for diagnosing breast health”, Sadr ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Joanne Mullarkey, Wayne Burrill, Laurence H. Patterson, Richard Linforth, Mohamed Salhab, Chris Sutton, Proteomics-Clinical Applications 2017, 1862-8354.
"Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450." Jonathan D. Sellars, Mark Skipsey, Sadr ul Shaheed, Hamza Abumansour, Klaus Pors, Laurence H. Patterson, and Chris W. Sutton. ChemMedChem 11, no. 11 (2016): 1122-1128.
“Identification of Stage-Specific Breast Markers Using Quantitative Proteomics”, Sadr ul Shaheed, Andrew Scally, Julie Wilson, Maria A Loizidou, Andreas Hadjisavvas, Andrew Hanby, Valerie Speirs, Paul Loadman, Chris W. Sutton, Journal of proteome research, 12 (2013), 5696-708.