Location

Oxford Blood Donor Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ

Chris Sutton, University of Bradford

Jan Lindeman, Leiden University, Netherlands

Professor Kyriacos Kyriacou, Cyprus Institute of Neurology and Genetics (CING), Cyprus

My work focuses on the identification of new diagnostic and prognostic biomarkers of organ injury and repair in solid organ transplantation. In collaboration with the Consortium for Organ Preservation in Europe (COPE) and the Quality in Organ Donation (QUOD) biobank, I have helped to develop new methods of generating multi-omics data from a range of biological materials e.g., tissue, blood, urine and bile. These methods will enable (i) the selection of viable organs for transplantation, (ii) the elucidation of the molecular pathways involved in the onset of organ ischemia and repair, and (iii) the identification of optimal interventions in perfusion models to reduce organ damage during the transplantation process.

After completing my Bachelor of Pharmacy degree at Bahauddin Zakariya University, Pakistan, I completed an MSc in Oncology at the University of Bradford in 2011. I then worked as a Proteomics Research Technician at the University of Bradford for 2 years and was involved in the development of liquid chromatography - mass spectrometry (LC-MS) methods for the identification of biomarkers in human cancers. In 2017, I completed my PhD at the Institute of Cancer Therapeutics, University of Bradford under the supervision of Professor Laurence Patterson and Dr Chris Sutton. My PhD focused on using proteomics for early detection and stratification of breast cancer subtypes. Following the completion of my PhD, I was involved in a drug development programme funded by Yorkshire Cancer Research UK for two years. In 2019, I moved to the Cancer Research UK Cambridge Institute and was involved in the management of a proteomics facility and developed new methods for protein analysis. In 2020, I joined the Transplantation Research Group in NDS as a Translational Omics Scientist.

Publications

“Proteomics analysis of colon cancer progression”, Saira Saleem, Sahrish Tariq, Iffat Aleem, Sadr ul Shaheed, Muhammad Tahseen, Aribah Atiq, Chris Sutton, Clinical proteomics 2019, 16:44

“Evaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer”, Sadr ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab, Chris Sutton, Clinical proteomics 2018, 1559-0275.

“Nipple aspirate fluid - a liquid biopsy for diagnosing breast health”, Sadr ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Joanne Mullarkey, Wayne Burrill, Laurence H. Patterson, Richard Linforth, Mohamed Salhab, Chris Sutton, Proteomics-Clinical Applications 2017, 1862-8354.

"Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450." Jonathan D. Sellars, Mark Skipsey, Sadr ul Shaheed, Hamza Abumansour, Klaus Pors, Laurence H. Patterson, and Chris W. Sutton. ChemMedChem 11, no. 11 (2016): 1122-1128.

“Identification of Stage-Specific Breast Markers Using Quantitative Proteomics”, Sadr ul Shaheed, Andrew Scally, Julie Wilson, Maria A Loizidou, Andreas Hadjisavvas, Andrew Hanby, Valerie Speirs, Paul Loadman, Chris W. Sutton, Journal of proteome research, 12 (2013), 5696-708.