Jessica Scaife
PhD
Research Manager
I have over twenty years experience designing experimental paradigms. A Neuropsychopharmacologist and Cognitive Neuroscientist, my research combines neuroimaging, electrophysiology and stimulation to investigate the neural and pharmacological basis of reward and emotion. During my 20 year postdoctoral career, I investigated brain function in both patient populations and healthy volunteers, using MRI and MEG. I ran studies in experimental medicine, Phase 1 and 3 clinical trials, including deep brain stimulation with Alex Green. I use mixed methods research to capture the lived experience of patients.
A member of the MSD PPI network, I lead PPI throughout trial development, and beyond, I am committed to developing and fostering greater connections with patient partners and charities.
I am passionate about public engagement and encouraging students to consider careers in STEM through events and work experience.
Recent publications
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Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.
Journal article
Perini F. et al, (2023), Schizophrenia (Heidelb), 9
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Catechol-O-methyltransferase activity does not influence emotional processing in men.
Journal article
Martens MA. et al, (2022), J Psychopharmacol
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A Longitudinal Magnetoencephalographic Study of the Effects of Deep Brain Stimulation on Neuronal Dynamics in Severe Anorexia Nervosa.
Journal article
Braeutigam S. et al, (2022), Front Behav Neurosci, 16
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Deep Brain Stimulation of the Nucleus Accumbens in Severe Enduring Anorexia Nervosa: A Pilot Study.
Journal article
Scaife JC. et al, (2022), Front Behav Neurosci, 16
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Translating the promise of 5HT4 receptor agonists for the treatment of depression.
Journal article
Murphy SE. et al, (2021), Psychol Med, 51, 1111 - 1120