Contact information
Colleges
Collaborators
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Alex Gordon-Weeks
Consultant Hepatobiliary Surgeon and Clinical Lecturer
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Keaton Jones
Senior Clinical Researcher
Adil Lakha
MB BChir MA (Cantab) MRCS
NIHR Academic Clinical Fellow in General Surgery
- Associate Surgical Specialty Lead for Liver Cancer, Association of Upper Gastrointestinal Surgery/Royal College of Surgeons England
- Teaching Associate, Green Templeton College, University of Oxford
My research focuses on translational and clinical aspects of hepatobiliary and pancreatic cancer surgery.
Embedded within the Gordon-Weeks group, my area of interest is the development of novel human models of the liver tumour-immune microenvironment at both tissue and organ level, through the use of slice cultures and ex vivo normothermic machine perfusion of resected liver specimens. This will help us to answer key questions and test tumour biology in clinically relevant disease models. Our goal is to de-risk clinical trials through the development of a high throughput, patient-specific, mechanistically driven approach to personalised cancer therapy.
My clinical research work is primarily through a national network working to deliver clinical trials in HPB surgery in the UK in areas such as hepatic artery infusion of chemotherapy, perioperative optimisation, and early phase trials in pancreatic surgery.
I am also involved in regular teaching for medical undergraduates as a Teaching Associate with Green Templeton College.
Recent publications
Can GLP-1RA be utilised for pre-operative liver optimisation prior to hepatectomy? A scoping review of MASLD evidence with surgical translation
Journal article
Vaitha R. et al, (2026), Clinical Surgical Oncology, 5, 100136 - 100136
Clinician and patient attitudes toward locoregional treatment of oligometastatic oesophago-gastric cancers: a mixed-methods study
Journal article
Lakha AS. et al, (2026), ESMO Gastrointestinal Oncology, 13, 100382 - 100382
Evidence of endothelial anergy and T-cell exclusion in microsatellite stable colorectal liver metastases revealed through human hemi-liver perfusion and spatial transcriptomics.
Journal article
Wan PK-T. et al, (2026), Mol Cancer
Benefit of adjuvant chemotherapy for resected pancreatic cancer following neoadjuvant FOLFIRINOX or Gemcitabine-Nab-paclitaxel: a multinational analysis.
Journal article
Lopez-Lopez V. et al, (2026), J Natl Cancer Inst
CT radiomics for survival risk stratification in resectable colorectal liver metastases: a multi-centre study.
Journal article
Mian A. et al, (2026), Sci Rep, 16